ADP-ribosyl cyclase



ADP-ribosyl cyclase (ADPRC) is the Aplysia californica homolog of CD38. It catalyzes the synthesis and hydrolysis of cyclic ADP-ribose. It uses NAD+ as substrate and produces cyclic ADP-ribose (cADPR). The images at the left and at the right correspond to one representative ADPRC, i.e. the crystal structure of ADP-ribosyl cyclase (1r12).

ADPRC
1r12 - ADPRC

1r0s – ADPRC (mutant)

ADPRC+ligand
1r15 - ADPRC+nicotinamide

3i9j – ADPRC+nicotinamide+2F-NAD+2F-ADPRI

3i9k – ADPRC (mutant)+NAD

3i9l – ADPRC (mutant)+N1-CIDPR

3i9o – ADPRC+Ribosyl-2F-ADPR

1r16 - ADPRC+3-pyridinylcarbinol